The most selective are usually heptane, d-limonene, and acetone. Second to them are usually DCM, chloroform and ether.
They usually extract a broader range of junk than all of the other solvents. In this regard the alcohols are usually considered the worst (IPA, ethanol, methanol). It’s best to find the most selecting solvent possible for the target alkaloid. Polarity is not the only thing you want to take note of when extracting. The same problem exists with the Polarity Index where IPA is shown as less polar than MEK. For example, the XlogP of MEK is the same as IPA, but MEK is actually less water soluble than IPA. The XlogP and Polarity Index should be treated as a rough guide as they are not accurate, especially when talking about specific alkaloid solubility or water solubility. But the acetone is used as nail polish remover and usually has other things added to it so it needs to be distilled. Isopropyl alcohol and Acetone found in drug stores are USP grade, which is extremely pure. The other solvents are hard to get in food grade form unless you buy from a chemical supply store. D-Limonene can also be obtained on-line in food grade form. However, you can easily get it in food grade form at many online vitamin shops. Here you can also see that Dimethyl Sulfoxide is the most polar, other than water.ĭimethyl Sulfoxide is hard to work with because it has a very high boiling point and takes forever to evaporate. Here's a useful link showing a different rating system called the polarity index. It’s insoluble in D-Limonese, n-Heptane, etc. For example, DMT citrate is more soluble IPA than in acetone. DMT’s solubility doesn’t exactly follow the XlogP of the solvents. They should dissolve easily in DMSO, methanol, alcohol, but not so well in acetone, MEK, etc. SWIM tested solubility of DMSO and found that 1 drop could easily dissolve 1 mg of DMT in about 1 second.ĭMT salts are usually the opposite. It is quite soluble in DMSO despite the high polarity of it. Freebase DMT is far more soluble in acetone than in n-Heptane (which is similar to naphtha). As the XlogP goes up past MEK, to solvents like Ether, DCM, etc, the solubility starts to drop a little. See the following very helpful PubChem link:įreebase DMT will dissolve in all of the above, especially acetone, IPA, and MEK. You can use PubChem to find the XlogP of almost every chemical there is. You can see that DMSO is the most polar of these. Here are the XlogP numbers of several common solvents listed from least polar at the top to most polar at the bottom. or do you mean that when defatting you have too many emulsions?ĭistilled water that is 10% sodium chloride (table salt) is more polar that pure water and pulls less junk out. IPA will pull a lot more oils and tanins then water.ĭmt is freely soluble in alcohol but yes so are a great many other things. My question is : is there a more selective polar solvent instead of water? I heard about good results with Isopropilic alcohol but i'm not sure it can get all the dmt salt. Distilled water works great as polar solvent but it takes too much things with dmt salt such as tannins, this cause bad emulsions and SWIM always has to work with a lot of solution to keep density low.
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